Can You Take Huperzine A and Oxiracetam Together?

Use extra care with this pair

The short answer

Oxiracetam enhances cholinergic neurotransmission and increases acetylcholine release, while Huperzine A inhibits acetylcholine degradation. This combination may cause excessive cholinergic stimulation.

How to arrange timing

Use lower doses of both when combining, and monitor for signs of cholinergic excess such as nausea, sweating, or muscle cramping.

Reference

Reference noted for this combination: Fordyce DE, et al. Enhancement of hippocampally-mediated learning and protein kinase C activity by oxiracetam in learning-impaired DBA/2 mice. Brain Res. 1995;672(1-2):170-176.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.