Can You Take Hordenine and Melatonin Together?

Dose or timing may matter

The short answer

Hordenine acts as an MAO-B inhibitor and sympathomimetic stimulant, which may counteract melatonin's sleep-promoting effects.

How to arrange timing

Avoid hordenine in the evening if using melatonin for sleep.

Reference

Reference noted for this combination: Barwell et al., 1989, J Pharm Pharmacol

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.