Can You Take Guarana and Melatonin Together?

Dose or timing may matter

The short answer

Guarana contains caffeine and other xanthines that may counteract melatonin's sleep-promoting effects.

How to arrange timing

Avoid guarana in the evening if taking melatonin for sleep.

Reference

Reference noted for this combination: Haskell et al., 2007, J Psychopharmacol

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.