Can You Take Greater Celandine and Kratom Together?

Use extra care with this pair

The short answer

Both Greater Celandine and Kratom cause cholestatic liver injury. Greater Celandine via isoquinoline alkaloids, Kratom via mitragynine. Same-mechanism stacking may amplify cholestatic damage.

How to arrange timing

Avoid combining. Both cause cholestatic injury through different alkaloids, which may produce additive biliary damage.

Reference

Reference noted for this combination: Benninger J et al., J Hepatol 1999; Kapp FG et al., Drug Alcohol Depend 2011

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.