Can You Take Greater Celandine and Kava Together?

Use extra care with this pair

The short answer

Both Greater Celandine and Kava are well-documented hepatotoxins. Greater Celandine's isoquinoline alkaloids cause cholestatic injury, while kavalactones cause hepatocellular damage.

How to arrange timing

Avoid this combination. Both have been associated with severe liver injury requiring medical intervention.

Reference

Reference noted for this combination: Benninger J et al., J Hepatol 1999; Teschke R., Ann Intern Med 2010; LiverTox (NIH/NLM)

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.