Can You Take Grape Seed Extract and Skullcap Together?

Use extra care with this pair

The short answer

Grape Seed Extract inhibits platelet aggregation via proanthocyanidins, while Skullcap has antiplatelet or blood-thinning properties. Taking both may amplify blood-thinning effects through different mechanisms.

How to arrange timing

Both Grape Seed Extract and Skullcap may affect blood clotting through different pathways. Consider monitoring for signs of increased bleeding (easy bruising, prolonged cuts) when taking both supplements together.

Reference

Reference noted for this combination: Murphy KJ et al., American Journal of Clinical Nutrition, 2003; Proanthocyanidins and platelet function

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.