Can You Take Grape Seed Extract and Proanthocyanidins Together?

Use extra care with this pair

The short answer

Both Grape Seed Extract and Proanthocyanidins are rich in proanthocyanidins that inhibit platelet aggregation. Stacking increases total antiplatelet polyphenol intake.

How to arrange timing

Both Grape Seed Extract and Proanthocyanidins affect blood clotting through similar mechanisms. Consider whether both are needed, or reduce doses when combining. Watch for signs of easy bruising.

Reference

Reference noted for this combination: Murphy KJ et al., American Journal of Clinical Nutrition, 2003; Proanthocyanidins and platelet function

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.