Can You Take Grape Seed Extract and Nattokinase Together?

Use extra care with this pair

The short answer

Grape Seed Extract inhibits platelet aggregation via proanthocyanidins, while Nattokinase breaks down fibrin clots. Taking both may amplify blood-thinning effects through different mechanisms.

How to arrange timing

Research suggests combining fibrinolytic enzymes like Nattokinase with other blood-thinning supplements like Grape Seed Extract may increase bleeding risk. Consider consulting a healthcare provider before stacking.

Reference

Reference noted for this combination: Pais-Morales J et al., Journal of Thrombosis and Haemostasis, 2020; Natural Medicines Comprehensive Database

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.