Can You Take Grape Seed Extract and L-Arginine Together?

Dose or timing may matter

The short answer

Grape seed extract lowers blood pressure via OPC-mediated vasodilation and eNOS activation, while L-Arginine provides NO substrate. The combination may cause additive vasodilation and BP lowering.

How to arrange timing

Monitor blood pressure when combining. Consider starting with lower doses of each.

Reference

Reference noted for this combination: Feringa HH et al. The effect of grape seed extract on cardiovascular risk markers. J Am Diet Assoc. 2011;111(8):1173-1181

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.