Can You Take Folate and Pancreatin Together?

May affect absorption

The short answer

Pancreatin contains enzymes that can interfere with the absorption of folate. The protease component may degrade folate-binding proteins, and the altered digestive environment may reduce folate bioavailability.

How to arrange timing

Take folate supplements at least 1 hour apart from pancreatin.

Reference

Reference noted for this combination: Russell RM, et al. Impairment of folic acid absorption by oral pancreatic extracts. Dig Dis Sci. 1980;25(5):369-373.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.