Can You Take Fo-Ti (He Shou Wu) and Neem Together?

Use extra care with this pair

The short answer

Fo-Ti has well-documented hepatotoxicity from anthraquinones. Neem (azadirachtin) has case reports of liver injury, especially at high doses. Combined use may increase hepatotoxicity risk.

How to arrange timing

Monitor liver function if using both. Research suggests limiting the dose and duration of concurrent use.

Reference

Reference noted for this combination: Lei X et al., J Ethnopharmacol 2015; LiverTox (NIH/NLM)

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.