Can You Take Fo-Ti (He Shou Wu) and Kratom Together?

Use extra care with this pair

The short answer

Both Fo-Ti (He Shou Wu) and Kratom are hepatotoxic. Fo-Ti's anthraquinones cause idiosyncratic liver injury, while Kratom's mitragynine causes cholestatic damage. Together they may affect the liver through different pathways.

How to arrange timing

Avoid this combination. Both substances have individually caused serious liver injury. If either is used, monitor liver function.

Reference

Reference noted for this combination: Lei X et al., J Ethnopharmacol 2015; Kapp FG et al., Drug Alcohol Depend 2011; LiverTox (NIH/NLM)

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.