Can You Take Fo-Ti (He Shou Wu) and Greater Celandine Together?

Use extra care with this pair

The short answer

Both Greater Celandine and Fo-Ti are documented hepatotoxins. Greater Celandine's isoquinoline alkaloids cause cholestatic injury, while Fo-Ti's anthraquinones cause hepatocellular damage.

How to arrange timing

Avoid concurrent use. Monitor liver function if either supplement is used individually.

Reference

Reference noted for this combination: Benninger J et al., J Hepatol 1999; Lei X et al., J Ethnopharmacol 2015; LiverTox (NIH/NLM)

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.