Can You Take Fish Oil (Omega-3) and Systemic Enzymes Together?

Use extra care with this pair

The short answer

Systemic enzymes (which typically include proteolytic enzymes like bromelain, serrapeptase, and trypsin) have anticoagulant and anti-platelet properties. Fish oil also inhibits platelet aggregation via omega-3 fatty acids. Combining them may produce an additive bleeding risk.

How to arrange timing

Use caution when combining systemic enzymes with fish oil. Monitor for signs of easy bruising or prolonged bleeding, especially before surgical procedures.

Reference

Reference noted for this combination: Leipner J, Saller R. Systemic enzyme therapy in oncology. Drugs. 2000;59(4):769-780.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.