Can You Take Fish Oil (Omega-3) and Superoxide Dismutase Together?

Dose or timing may matter

The short answer

Superoxide Dismutase (SOD) is a potent antioxidant enzyme that neutralizes superoxide radicals. Fish oil's omega-3 fatty acids are susceptible to oxidation, and SOD may alter the redox environment affecting omega-3 metabolism and signaling.

How to arrange timing

Consider separating SOD supplements from fish oil. The interaction is generally mild but may affect the signaling benefits of omega-3 fatty acids.

Reference

Reference noted for this combination: McCord JM, Fridovich I. Superoxide dismutase: an enzymic function for erythrocuprein (hemocuprein). J Biol Chem. 1969;244(22):6049-6055.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.