Can You Take Fish Oil (Omega-3) and Shiitake Extract Together?

May affect absorption

The short answer

Shiitake mushroom contains eritadenine and lentinan which may have mild antiplatelet effects. Fish oil (omega-3) also inhibits platelet aggregation. Combined use may slightly increase bleeding tendency.

How to arrange timing

Generally safe to combine, but monitor for unusual bruising. Discontinue both before surgical procedures.

Reference

Reference noted for this combination: Enman J et al., Journal of the Science of Food and Agriculture, 2007; Lentinula edodes bioactive compounds

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.