Can You Take Green Tea Extract (EGCG) and Kratom Together?

Use extra care with this pair

The short answer

Both EGCG and Kratom have documented hepatotoxicity. High-dose EGCG causes oxidative hepatocellular injury, while Kratom's mitragynine causes cholestatic liver damage. Combined use affects the liver through complementary toxic mechanisms.

How to arrange timing

Avoid combining concentrated EGCG supplements with Kratom. If using Kratom, avoid adding other hepatotoxic supplements.

Reference

Reference noted for this combination: Navarro VJ et al., Hepatology 2017; Kapp FG et al., Drug Alcohol Depend 2011; LiverTox (NIH/NLM)

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.