Can You Take Echinacea and Shiitake Extract Together?

Dose or timing may matter

The short answer

Shiitake extract contains lentinan, a potent beta-glucan that strongly activates macrophages, NK cells, and T-cells. Echinacea also stimulates innate immune responses. Combined use may cause excessive immune stimulation in individuals with autoimmune conditions.

How to arrange timing

If using both Shiitake extract and Echinacea for immune support, consider cycling rather than continuous combined use. Avoid if you have autoimmune conditions.

Reference

Reference noted for this combination: Chihara G et al., Cancer Research, 1970; Lentinan immunostimulatory properties; Block KI, Mead MN, Integr Cancer Ther, 2003

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.