Can You Take DMHA and Synephrine Together?

Use extra care with this pair

The short answer

DMHA and synephrine are both sympathomimetic stimulants. DMHA releases norepinephrine while synephrine activates beta-3 adrenergic receptors. Their combined adrenergic stimulation may cause excessive cardiovascular stress.

How to arrange timing

Avoid combining multiple sympathomimetic stimulants. If combining, reduce doses significantly and monitor cardiovascular response.

Reference

Reference noted for this combination: Cohen PA et al. A synthetic stimulant never tested in humans, 1,3-dimethylbutylamine (DMBA), is identified in multiple dietary supplements. Drug Test Anal. 2016;8(8):836-843

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.