Can You Take DHEA and St. John's Wort Together?

Dose or timing may matter

The short answer

St. John's Wort may increase metabolism of DHEA via CYP3A4 induction, reducing its effectiveness.

How to arrange timing

Avoid combining.

Reference

Reference noted for this combination: Examine.com 2024

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.