Can You Take DHEA and Indole-3-Carbinol Together?

Dose or timing may matter

The short answer

Indole-3-carbinol (I3C) enhances estrogen clearance via CYP1A1 induction and 2-hydroxylation, potentially reducing the estrogenic hormonal effects that DHEA supplementation aims to provide.

How to arrange timing

If using DHEA for hormonal support, be aware that I3C may counteract some estrogenic effects.

Reference

Reference noted for this combination: Michnovicz JJ et al. Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment. J Natl Cancer Inst. 1997;89(10):718-723

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.