Can You Take Danshen (Salvia miltiorrhiza) and St. John's Wort Together?

Use extra care with this pair

The short answer

St. John's Wort increases serotonin levels, and Danshen (tanshinone) has demonstrated serotonergic effects. Together, they may amplify serotonergic effects beyond safe levels.

How to arrange timing

Monitor for signs of excess serotonin (agitation, tremor, sweating) when combining St. John's Wort and Danshen. Consider reducing doses or using them at different times.

Reference

Reference noted for this combination: Franconi G, et al. Serotonin syndrome caused by drug-drug interactions with supplements. J Clin Pharm Ther. 2014;39(4):339-342.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.