Can You Take Rhubarb Root and Fo-Ti (He Shou Wu) Together?

Use extra care with this pair

The short answer

Both Rhubarb Root and Fo-Ti contain anthraquinone compounds with hepatotoxic potential. Fo-Ti is one of the most frequently reported causes of herb-induced liver injury in China. Combined anthraquinone load amplifies risk.

How to arrange timing

Research suggests avoiding concurrent use of multiple anthraquinone-containing herbs. If either is used, monitor liver enzymes and limit duration.

Reference

Reference noted for this combination: Lei X et al., J Ethnopharmacol 2015; Beuers U et al., Gastroenterology 1991

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.