Can You Take Cyanocobalamin and Folate Together?

Dose or timing may matter

The short answer

High-dose folic acid can mask the hematological signs of vitamin B12 (cyanocobalamin) deficiency by correcting megaloblastic anemia while allowing neurological damage to progress undetected.

How to arrange timing

When supplementing high-dose folate, ensure adequate B12 status. Consider B12 testing before starting high-dose folate therapy.

Reference

Reference noted for this combination: Reynolds EH. The neurology of folic acid deficiency. Handb Clin Neurol. 2014;120:927-943

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.