Can You Take Comfrey and Greater Celandine Together?

Use extra care with this pair

The short answer

Both Comfrey and Greater Celandine are established hepatotoxins. Comfrey's pyrrolizidine alkaloids cause veno-occlusive disease, while Greater Celandine's isoquinoline alkaloids cause cholestatic injury.

How to arrange timing

Avoid this combination. Both are subject to regulatory warnings for hepatotoxicity in multiple countries.

Reference

Reference noted for this combination: Teschke R. et al., Ann Hepatol 2012; Benninger J et al., J Hepatol 1999

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.