Can You Take Comfrey and Green Tea Extract (EGCG) Together?

Use extra care with this pair

The short answer

Comfrey's pyrrolizidine alkaloids cause hepatic veno-occlusive disease. High-dose EGCG causes oxidative hepatocellular injury. Combined use exposes the liver to multiple toxic pathways.

How to arrange timing

Avoid this combination. Comfrey is already restricted for oral use. Do not combine it with other hepatotoxic supplements.

Reference

Reference noted for this combination: Teschke R. et al., Ann Hepatol 2012; Navarro VJ et al., Hepatology 2017

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.