Can You Take Coltsfoot and Greater Celandine Together?

Use extra care with this pair

The short answer

Coltsfoot's pyrrolizidine alkaloids and Greater Celandine's isoquinoline alkaloids both cause liver injury through different toxic mechanisms. Combined exposure increases overall hepatotoxicity risk.

How to arrange timing

Avoid combining PA-containing herbs with other hepatotoxic botanicals. Monitor liver function if either is used.

Reference

Reference noted for this combination: Teschke R. et al., Ann Hepatol 2012; Benninger J et al., J Hepatol 1999

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.