Can You Take Coltsfoot and Comfrey Together?

Use extra care with this pair

The short answer

Both Comfrey and Coltsfoot contain pyrrolizidine alkaloids (PAs), which cause hepatic veno-occlusive disease (sinusoidal obstruction syndrome). Combined use significantly increases total PA exposure and liver toxicity risk.

How to arrange timing

Avoid combining PA-containing herbs. Cumulative PA intake is the primary risk factor for veno-occlusive disease. Consider PA-free alternatives.

Reference

Reference noted for this combination: Teschke R. et al., Ann Hepatol 2012; EFSA Scientific Opinion on PAs, 2011

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.