Can You Take Citrulline and Pine Bark Extract Together?

Dose or timing may matter

The short answer

Both citrulline and pine bark extract (Pycnogenol) increase nitric oxide bioavailability. Citrulline provides the NO substrate while pine bark activates endothelial NOS. Dual-mechanism NO boosting may cause excessive vasodilation.

How to arrange timing

Monitor blood pressure when combining these nitric oxide enhancers. Research suggests starting with lower doses.

Reference

Reference noted for this combination: Enseleit F et al. Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease. Eur Heart J. 2012;33(13):1589-1597

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.