Can You Take Chaparral and Greater Celandine Together?

Use extra care with this pair

The short answer

Both Chaparral and Greater Celandine are established hepatotoxins. Chaparral's nordihydroguaiaretic acid causes acute hepatitis, while Greater Celandine's isoquinoline alkaloids cause cholestatic liver injury.

How to arrange timing

Avoid this combination. Both have been subject to regulatory actions due to hepatotoxicity concerns.

Reference

Reference noted for this combination: Sheikh NM et al., Arch Intern Med 1997; Benninger J et al., J Hepatol 1999; LiverTox (NIH/NLM)

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.