Can You Take Chaparral and Comfrey Together?

Use extra care with this pair

The short answer

Both Chaparral and Comfrey are potent hepatotoxins. Chaparral causes acute hepatitis via nordihydroguaiaretic acid, while Comfrey's pyrrolizidine alkaloids cause veno-occlusive disease. This is a high-risk hepatotoxicity combination.

How to arrange timing

Strongly avoid this combination. Both are among the most hepatotoxic dietary supplements documented in medical literature.

Reference

Reference noted for this combination: Sheikh NM et al., Arch Intern Med 1997; Teschke R. et al., Ann Hepatol 2012; LiverTox (NIH/NLM)

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.