Can You Take Cerebrolysin and Lion's Mane Together?

Dose or timing may matter

The short answer

Cerebrolysin and Lion's Mane both promote nerve growth factor (NGF) signaling. Stacking two NGF-enhancing agents may cause excessive neurotrophic stimulation, the long-term effects of which are not well characterized.

How to arrange timing

Use one neurotrophic agent at a time unless directed by a healthcare provider. If combining, monitor for unusual neurological symptoms.

Reference

Reference noted for this combination: Muresanu DF, et al. Cerebrolysin and Recovery After Stroke (CARS): a randomized, placebo-controlled, double-blind, multicenter trial. Ann N Y Acad Sci. 2012;1270:77-85.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.