Can You Take Centrophenoxine and Huperzine A Together?

Use extra care with this pair

The short answer

Centrophenoxine is a cholinergic compound (a DMAE ester) that increases acetylcholine levels. Combined with Huperzine A, a potent acetylcholinesterase inhibitor, this can cause significant cholinergic excess.

How to arrange timing

Avoid combining, or use only under professional supervision with significantly reduced doses of both.

Reference

Reference noted for this combination: Marcer D, Hopkins SM. The differential effects of meclofenoxate on memory loss in the elderly. Age Ageing. 1977;6(2):123-131.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.