Can You Take CBD (Cannabidiol) and Skullcap Together?

Use extra care with this pair

The short answer

CBD's CNS calming effects combined with skullcap's GABAergic action may cause excessive sedation.

How to arrange timing

Monitor for excessive drowsiness if combining.

Reference

Reference noted for this combination: Shannon et al., 2019, Perm J

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.