Can You Take Calcium and Mannan Oligosaccharides (MOS) Together?

May affect absorption

The short answer

Mannan Oligosaccharides (MOS) are soluble fibers that may bind calcium in the GI tract, reducing its absorption when taken simultaneously.

How to arrange timing

Separate mannan oligosaccharides and calcium supplements by at least 2 hours for optimal absorption.

Reference

Reference noted for this combination: NIH ODS; NatMed Pro Fiber Monograph; Bosscher D et al., Eur J Nutr 2003

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.