Can You Take Calcium and Isomalto-oligosaccharides (IMO) Together?

May affect absorption

The short answer

Isomalto-oligosaccharides (IMO) are soluble fibers that may transiently bind calcium in the upper GI tract, reducing its absorption when taken simultaneously.

How to arrange timing

Separate isomalto-oligosaccharides and calcium supplements by at least 2 hours for optimal absorption.

Reference

Reference noted for this combination: NIH ODS; NatMed Pro Fiber Monograph; Bosscher D et al., Eur J Nutr 2003

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.