Can You Take Caffeine and Yohimbine Together?

Dose or timing may matter

The short answer

Caffeine and yohimbine both raise blood pressure through sympathomimetic mechanisms. Their combined use may produce additive pressor effects and cardiovascular stress.

How to arrange timing

Research suggests caution with this combination. Both raise BP and heart rate; monitor cardiovascular parameters closely.

Reference

Reference noted for this combination: Galitzky J et al. Alpha 2-antagonist compounds and lipid mobilization. Int J Obes. 1993;17(Suppl 3):S104-S109

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.