Can You Take Caffeine and Wild Lettuce Together?

Dose or timing may matter

The short answer

Caffeine may counteract wild lettuce's mild sedative and analgesic effects.

How to arrange timing

Separate by several hours if using wild lettuce for relaxation.

Reference

Reference noted for this combination: Wesolowska et al., 2006, J Ethnopharmacol

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.