Can You Take Caffeine and Sunifiram Together?

Dose or timing may matter

The short answer

Sunifiram enhances AMPA receptor function and has stimulant-like cognitive effects. Caffeine is a CNS stimulant. Combining two stimulating compounds may cause excessive arousal, anxiety, and restlessness.

How to arrange timing

Reduce caffeine intake when using Sunifiram. Both are CNS stimulants, and additive effects may cause overstimulation.

Reference

Reference noted for this combination: Galeotti N, et al. Suniferam (DM-235) enhances spatial learning and memory in mice through activation of AMPA receptor. Behavioural Brain Res. 2013;253:41-47.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.