Can You Take Caffeine and Skullcap Together?

Dose or timing may matter

The short answer

Caffeine's CNS stimulation may counteract skullcap's GABAergic sedative effects.

How to arrange timing

Separate intake by several hours.

Reference

Reference noted for this combination: Awad et al., 2003, Phytomedicine

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.