Can You Take Caffeine and PT-141 (Bremelanotide) Together?

Use extra care with this pair

The short answer

PT-141 (Bremelanotide) can increase blood pressure and heart rate through melanocortin receptor activation. Caffeine amplifies these cardiovascular effects. The combination may cause additive cardiovascular stress.

How to arrange timing

Reduce caffeine intake on days when using PT-141. Monitor blood pressure and heart rate.

Reference

Reference noted for this combination: Diamond LE, et al. An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141). J Sex Med. 2006;3(4):628-638.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.