Can You Take Caffeine and Octopamine Together?

Use extra care with this pair

The short answer

Octopamine is a trace amine with sympathomimetic properties that increases norepinephrine release. Combined with caffeine, the additive adrenergic stimulation may cause excessive cardiovascular stress including hypertension and tachycardia.

How to arrange timing

Reduce doses when combining stimulants. Monitor heart rate and blood pressure. Contraindicated for individuals with cardiovascular disease.

Reference

Reference noted for this combination: Stohs SJ et al. A review of the receptor-binding properties of p-synephrine as related to its pharmacological effects. Oxid Med Cell Longev. 2015;2015:142070

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.