Can You Take Caffeine and Melanotan II Together?

Use extra care with this pair

The short answer

Melanotan II can increase blood pressure through melanocortin receptor activation. Caffeine also raises blood pressure via sympathetic stimulation. The combination may cause additive cardiovascular stress.

How to arrange timing

Monitor blood pressure when using Melanotan II with caffeine. Consider reducing caffeine intake during Melanotan II use.

Reference

Reference noted for this combination: Hadley ME, Dorr RT. Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides. 2006;27(4):921-930.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.