Can You Take Caffeine and Higenamine Together?

Use extra care with this pair

The short answer

Higenamine is a beta-2 adrenergic agonist that increases heart rate and cardiac output. Combined with caffeine's sympathomimetic effects, the additive cardiovascular stimulation may cause tachycardia, arrhythmia, and excessive blood pressure elevation.

How to arrange timing

Use caution combining these stimulants. Start with minimal doses and monitor cardiovascular response. Avoid with pre-existing heart conditions.

Reference

Reference noted for this combination: Bloomer RJ et al. Acute hemodynamic responses to higenamine in healthy humans. Int J Med Sci. 2015;12(12):902-907

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.