Can You Take Bromelain and Protease Together?

Use extra care with this pair

The short answer

Both Bromelain and Protease are proteolytic enzymes with fibrinolytic and anti-inflammatory activity. Combining them stacks their anticoagulant and anti-platelet effects, potentially increasing bleeding risk.

How to arrange timing

Exercise caution when combining Bromelain and Protease supplements. Monitor for signs of easy bruising or prolonged bleeding.

Reference

Reference noted for this combination: Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001;58(9):1234-1245.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.