Can You Take BPC-157 and L-Arginine Together?

Use extra care with this pair

The short answer

BPC-157 upregulates nitric oxide (NO) synthesis pathways, and L-Arginine is the direct precursor for NO production via eNOS. Combining them may lead to excessive NO levels, potentially causing hypotension.

How to arrange timing

Research suggests monitoring blood pressure when combining BPC-157 with L-Arginine. Start with lower doses of each.

Reference

Reference noted for this combination: Sikiric P, et al. Stable gastric pentadecapeptide BPC 157 and NO system. Curr Pharm Des. 2014;20(7):1126-1135.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.