Can You Take Black Cohosh and Kratom Together?

Use extra care with this pair

The short answer

Both Black Cohosh and Kratom are hepatotoxic. Black Cohosh may trigger autoimmune hepatitis, while Kratom causes cholestatic liver injury. Different mechanisms may produce additive liver damage.

How to arrange timing

Avoid this combination. Both are among the most commonly reported causes of supplement-induced liver injury. Monitor liver function if either is used.

Reference

Reference noted for this combination: Mahady GB et al., Menopause 2008; Kapp FG et al., Drug Alcohol Depend 2011; LiverTox (NIH/NLM)

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.