Can You Take Beta-Phenylethylamine and Caffeine Together?

Use extra care with this pair

The short answer

Beta-Phenylethylamine (PEA) is a trace amine that stimulates catecholamine release, and caffeine potentiates sympathomimetic effects. Combining them may lead to excessive cardiovascular stimulation including elevated heart rate and blood pressure.

How to arrange timing

Use caution when combining PEA with caffeine. Start with low doses and monitor heart rate and blood pressure.

Reference

Reference noted for this combination: Berry MD. Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators. J Neurochem. 2004;90(2):257-271.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.