Can You Take Berberine and Lactobacillus casei Shirota Together?

Dose or timing may matter

The short answer

Berberine has broad-spectrum antimicrobial activity that may reduce the viability of Lactobacillus casei Shirota when taken simultaneously.

How to arrange timing

Separate berberine and Lactobacillus casei Shirota by at least 2 hours to protect probiotic viability.

Reference

Reference noted for this combination: J Ethnopharmacol 2014; Examine.com Berberine

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.