Can You Take Berberine and Inonotus Obliquus Together?

Dose or timing may matter

The short answer

Inonotus obliquus polysaccharides have demonstrated hypoglycemic effects by enhancing insulin sensitivity in animal models. Berberine also lowers blood glucose via AMPK activation. Combined use may lead to excessive blood sugar reduction.

How to arrange timing

Monitor blood sugar levels closely when combining Inonotus obliquus with Berberine, especially if on glucose-lowering medications.

Reference

Reference noted for this combination: Wang J et al., International Journal of Biological Macromolecules, 2017; Inonotus obliquus polysaccharides and hypoglycemia

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.